|
Symbol Name ID |
Atm
ataxia telangiectasia mutated MGI:107202 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating IgG2 level |
Defective B cell differentiation |
| Disease(s) Associated with ATM | ||||
| ataxia telangiectasia |
| Mouse Phenotypes | cellular phenotype |
abnormal fat cell differentiation |
absent oocytes |
azoospermia |
abnormal spermatid morphology |
abnormal spermatocyte morphology |
abnormal chromosome morphology |
abnormal lysosome morphology |
abnormal cell cycle |
abnormal cell cycle checkpoint function |
abnormal female meiosis |
arrest of male meiosis |
decreased sensitivity to induced cell death |
decreased cellular sensitivity to ionizing radiation |
decreased cellular sensitivity to gamma-irradiation |
increased cellular sensitivity to ionizing radiation |
increased cellular sensitivity to gamma-irradiation |
abnormal oogenesis |
decreased fibroblast proliferation |
decreased cell proliferation |
abnormal DNA repair |
chromosomal instability |
chromosome breakage |
spontaneous chromosome breakage |
oxidative stress |
impaired macrophage phagocytosis |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||
| Atmm5Btlr/Atmm5Btlr | |||||||||||||||||||||||||||
| Atmtm1.1Mmpl/Atmtm1.1Mmpl | |||||||||||||||||||||||||||
| Atmtm1Awb/Atmtm1Awb | * | ||||||||||||||||||||||||||
| Atmtm1Bal/Atmtm1Bal | |||||||||||||||||||||||||||
| Atmtm1Fwa/Atmtm1Fwa | |||||||||||||||||||||||||||
| Atmtm1Led/Atmtm1Led | |||||||||||||||||||||||||||
| Atmtm1Mfl/Atmtm1Mfl | |||||||||||||||||||||||||||
| Atmtm1Pmc/Atmtm1Pmc | |||||||||||||||||||||||||||
| Atmtm2Pmc/Atmtm2Pmc Meox2tm1(cre)Sor/Meox2+ (conditional) |
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| Atmtm1Shzh/Atmtm2.1Fwa (conditional) | |||||||||||||||||||||||||||
| Atmtm1Shzh/Atmtm2.1Fwa Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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