Symbol
Name
ID

Tnf
tumor necrosis factor
MGI:104798

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgE level	Increased circulating IgG level	Polyclonal elevation of IgM	Decreased circulating antibody level	Increased circulating antibody level	Paraproteinemia
Disease(s) Associated with TNF	Increased circulating IgA level	Increased circulating IgE level	Increased circulating IgG level	Polyclonal elevation of IgM	Decreased circulating antibody level	Increased circulating antibody level	Paraproteinemia
Gaucher's disease
multiple myeloma
thrombocytopenia

Mouse Phenotypes

oligozoospermia

abnormal oligodendrocyte apoptosis

decreased apoptosis

increased apoptosis

hepatic necrosis

increased fibroblast cell migration

increased cell migration

increased fibroblast proliferation

decreased keratinocyte proliferation

increased cell proliferation

impaired macrophage phagocytosis

Availability

Mouse Genotype

Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug

Tnf^tm1Gkl/Tnf^tm1Gkl

Tnf^tm1Ljo/Tnf^tm1Ljo

Tnf^tm2Gkl/Tnf⁺

Tg(Tnf)6074Gkl/0

Tnf^tm1.1Sned/Tnf^tm1.1Sned
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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