Symbol
Name
ID

Vcl
vinculin
MGI:98927

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes

Cardiomyocyte hypertrophy

Endocardial fibrosis

Dilated cardiomyopathy

Hypertrophic cardiomyopathy

Apical hypertrophic cardiomyopathy

Myofiber disarray

Hyperdynamic left ventricular ejection fraction

Reduced left ventricular ejection fraction

Increased left ventricular end-diastolic volume

Left ventricular outflow tract obstruction

Pulmonary arterial hypertension

Congestive heart failure

Disease(s) Associated with VCL

dilated cardiomyopathy 1W

hypertrophic cardiomyopathy 15

Mouse Phenotypes

abnormal cardiovascular system morphology

dilated vasculature

abnormal myocardial fiber morphology

abnormal intercalated disk morphology

decreased myocardial fiber number

thin myocardium

abnormal heart development

absent atrioventricular cushions

delayed heart development

abnormal heart position or orientation

increased heart weight

cardiac hypertrophy

small heart

absent heart valves

dilated heart left ventricle

abnormal pericardial cavity morphology

cardiac fibrosis

dilated cardiomyopathy

abnormal cardiovascular system physiology

decreased cardiac muscle contractility

decreased ventricle muscle contractility

abnormal cardiac muscle relaxation

ventricular tachycardia

irregular heartbeat

abnormal impulse conducting system conduction

abnormal heart electrocardiography waveform feature

prolonged QRS complex duration

heart block

congestive heart failure

Availability

Mouse Genotype

Vcl^tm1.1Whz/Vcl^tm1.1Whz

Vcl^tm1Eda/Vcl^tm1Eda

Vcl^tm1Eda/Vcl⁺

Myl2^tm1(cre)Krc/Myl2⁺
Vcl^tm1Ross/Vcl^tm1Ross (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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