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Symbol
Name
ID
Ren1
renin 1 structural
MGI:97898
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Elevated diastolic blood pressure
Elevated mean arterial pressure
Elevated systolic blood pressure
Disease(s) Associated with REN
essential hypertension

Mouse Phenotypes
cardiovascular system phenotype
abnormal kidney afferent arteriole morphology
abnormal kidney interlobular artery morphology
vascular smooth muscle hyperplasia
cardiac hypertrophy
decreased heart rate
increased heart rate
decreased systemic arterial blood pressure
decreased mean systemic arterial blood pressure
decreased systemic arterial diastolic blood pressure
decreased systemic arterial systolic blood pressure
hypotension
increased systemic arterial blood pressure
hypertension
decreased vasoconstriction
Availability Mouse Genotype
Ren1tm1.2Sig/Ren1tm1.2Sig
Ren1tm1Afu/Ren1tm1Afu *
Ren1tm1Bjm/Ren1tm1Bjm *
Ren1tm1Gom/Ren1tm1Gom
Ren1tm1Mgfs/Ren1tm1Mgfs
Ren1tm1Tkh/Ren1tm1Tkh
Ren1tm3Gom/Ren1tm3Gom
Tg(Alb1-Ren)1Unc/0
Tg(Alb1-Ren)2Unc/0
Tg(Alb1-Ren)2Unc/?
Ren1tm1.1Sig/Ren1tm1.1Sig
Tg(GFAP-cre)25Mes/0  (conditional)
*
Ren1tm1.1Sig/Ren1tm1.1Sig
Tg(Nes-cre)1Kln/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory