Symbol
Name
ID

Pdgfrb
platelet derived growth factor receptor, beta polypeptide
MGI:97531

Phenotype annotations related to cardiovascular system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Calcification of the small brain vessels
Disease(s) Associated with PDGFRB	Calcification of the small brain vessels
basal ganglia calcification

Mouse Phenotypes

abnormal blood vessel morphology

abnormal pulmonary artery morphology

increased aorta wall thickness

right aortic arch

vascular ring

abnormal left subclavian artery morphology

abnormal vascular endothelial cell morphology

increased vascular endothelial cell number

decreased glomerular capillary number

abnormal retina vasculature morphology

abnormal retina blood vessel morphology

abnormal retina blood vessel pattern

abnormal kidney vasculature morphology

abnormal pericyte morphology

abnormal placenta vasculature

abnormal placental labyrinth vasculature morphology

abnormal angiogenesis

decreased angiogenesis

abnormal venule morphology

abnormal heart morphology

double outlet right ventricle

overriding aortic valve

dilated heart atrium

atrioventricular septal defect

perimembraneous ventricular septal defect

muscular ventricular septal defect

ventricular septal defect

enlarged heart

increased heart ventricle size

cardiac fibrosis

hemorrhage

eye hemorrhage

intracranial hemorrhage

kidney hemorrhage

glomerulus hemorrhage

skin hemorrhage

increased vascular permeability

Availability

Mouse Genotype

Pdgfrb^b2b2903Clo/Pdgfrb^b2b2903Clo

Pdgfrb^redeye/Pdgfrb^redeye

Pdgfrb^tm1Sor/Pdgfrb^tm1Sor

Pdgfrb^tm2Sor/Pdgfrb^tm2Sor

Pdgfrb^tm7Sor/Pdgfrb^tm7Sor

Pdgfrb^tm8Sor/Pdgfrb^tm8Sor

Pdgfrb^tm9Sor/Pdgfrb^tm9Sor

Pdgfrb^tm10Sor/Pdgfrb^tm10Sor

Pdgfrb^{tm1b(EUCOMM)Hmgu}/Pdgfrb⁺

Pdgfrb^tm1Sor/Pdgfrb^tm8Sor

Pdgfrb^tm1Sor/Pdgfrb^tm9Sor

Pdgfrb^tm1Mdt/Pdgfrb^tm1Mdt
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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