Symbol
Name
ID

Pdgfb
platelet derived growth factor, B polypeptide
MGI:97528

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Calcification of the small brain vessels
Disease(s) Associated with PDGFB	Calcification of the small brain vessels
basal ganglia calcification

Mouse Phenotypes

abnormal blood vessel morphology

abnormal artery morphology

abnormal aorta smooth muscle morphology

dilated aorta

abnormal vascular endothelial cell morphology

increased vascular endothelial cell number

abnormal capillary morphology

decreased capillary density

dilated glomerular capillary

increased capillary tortuosity

brain aneurysm

abnormal retina vasculature morphology

kidney microaneurysm

abnormal pericyte morphology

abnormal placenta vasculature

abnormal placental labyrinth vasculature morphology

abnormal vascular smooth muscle morphology

thin myocardium

abnormal coronary vessel morphology

enlarged heart

dilated heart left ventricle

abnormal heart right ventricle morphology

dilated heart right ventricle

hemorrhage

intracerebral hemorrhage

impaired blood-brain barrier function

congestive heart failure

Availability

Mouse Genotype

Pdgfb^tm1Cbet/Pdgfb^tm1Cbet

Pdgfb^tm3.1Cbet/Pdgfb^tm3.1Cbet

Pdgfb^tm3.1Cbet/Pdgfb^tm3.1Cbet
Tg(Fabp4-lacZ)4Mosh/0

Pdgfb^tm1Cbet/Pdgfb^tm3.1Cbet

Pdgfb^tm1Cbet/Pdgfb^tm2Cbet
Tg(Tie1-cre)9Ref/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23