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Symbol
Name
ID 		Mmp2
matrix metallopeptidase 2
MGI:97009
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Retinal hemorrhage
Cerebral hemorrhage
Bruising susceptibility
Retinal arteritis
Abnormal cardiovascular system morphology
Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis
Abnormal endocardium morphology
Mitral valve prolapse
Restrictive cardiomyopathy
Pericarditis
Abdominal aortic aneurysm
Aortic dissection
Coronary artery atherosclerosis
Medial calcification of large arteries
Medial calcification of medium-sized arteries
Arterial stenosis
Premature occlusive vascular stenosis
Arteriosclerosis
Atherosclerosis
Accelerated atherosclerosis
Vascular dilatation
Vasculitis
Abnormal cerebral vascular morphology
Stroke
Mitral stenosis
Hypertension
Renovascular hypertension
Weak pulse
Intermittent claudication
Cerebral ischemia
Arrhythmia
Sudden cardiac death
Angina pectoris
Congestive heart failure
Mediastinal lymphadenopathy
Telangiectasia of the skin
Disease(s) Associated with MMP2
pseudoxanthoma elasticum
temporal arteritis

Mouse Phenotypes
abnormal induced retina neovascularization
abnormal angiogenesis
decreased angiogenesis
abnormal heart morphology
enlarged heart
dilated heart left ventricle
abnormal cardiovascular system physiology
abnormal response to cardiac infarction
abnormal vascular smooth muscle physiology
Availability Mouse Genotype
Mmp2em1(IMPC)Mbp/Mmp2em1(IMPC)Mbp
Mmp2tm1Ito/Mmp2tm1Ito
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory