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Symbol Name ID |
Lmna
lamin A MGI:96794 |
| Darker colors indicate more annotations |
| Human Phenotypes | Intracranial hemorrhage |
Ventricular hypertrophy |
Abnormal aortic valve morphology |
Aortic valve calcification |
Abnormal mitral valve morphology |
Mitral valve calcification |
Abnormal myocardium morphology |
Cardiomyopathy |
Dilated cardiomyopathy |
Hypertrophic cardiomyopathy |
Interstitial cardiac fibrosis |
Pericardial effusion |
Pulmonary artery stenosis |
Carotid artery occlusion |
Coronary artery atherosclerosis |
Premature coronary artery atherosclerosis |
Atherosclerosis |
Precocious atherosclerosis |
Premature arteriosclerosis |
Prominent superficial veins |
Abnormal cerebral vascular morphology |
Stroke |
Transient ischemic attack |
Abnormal left ventricular function |
Reduced left ventricular ejection fraction |
Left ventricular diastolic dysfunction |
Left ventricular systolic dysfunction |
Aortic regurgitation |
Aortic valve stenosis |
Mitral regurgitation |
Mitral stenosis |
Hypertension |
Raynaud phenomenon |
Pulmonary arterial hypertension |
Arrhythmia |
Sinoatrial block |
Sinus bradycardia |
Sudden cardiac death |
Supraventricular arrhythmia |
Atrial fibrillation |
Paroxysmal atrial fibrillation |
Atrial flutter |
Supraventricular tachycardia |
Paroxysmal atrial tachycardia |
Ventricular tachycardia |
Ventricular arrhythmia |
Ventricular escape rhythm |
Cardiac conduction abnormality |
Atrioventricular block |
First degree atrioventricular block |
Second degree atrioventricular block |
Third degree atrioventricular block |
Heart block |
Left anterior fascicular block |
Myocardial infarction |
Angina pectoris |
Congestive heart failure |
Syncope |
Splenomegaly |
Prominent superficial blood vessels |
Telangiectasia of the skin |
| Disease(s) Associated with LMNA | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| autosomal dominant Emery-Dreifuss muscular dystrophy 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| autosomal recessive Emery-Dreifuss muscular dystrophy 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| congenital muscular dystrophy due to LMNA mutation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| dilated cardiomyopathy 1A | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Emery-Dreifuss muscular dystrophy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| familial partial lipodystrophy type 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| progeria | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Werner syndrome |
| Mouse Phenotypes | abnormal artery morphology |
abnormal aorta tunica adventitia morphology |
abnormal aorta smooth muscle morphology |
increased aorta wall thickness |
calcified aortic arch |
calcified thoracic aorta |
calcified aorta |
atherosclerotic lesions |
decreased vascular endothelial cell number |
decreased capillary density |
abnormal physiological neovascularization |
vascular smooth muscle hypoplasia |
abnormal myocardial fiber morphology |
decreased myocardial fiber number |
decreased myocardial fiber size |
myocardial fiber degeneration |
myocardium necrosis |
thin myocardium |
cardiac muscle degeneration |
abnormal heart development |
abnormal heart morphology |
increased heart atrium size |
dilated heart atrium |
decreased heart weight |
enlarged heart |
cardiac hypertrophy |
small heart |
abnormal heart left ventricle morphology |
decreased heart left ventricle weight |
dilated heart left ventricle |
dilated heart right ventricle |
cardiac fibrosis |
cardiac interstitial fibrosis |
dilated cardiomyopathy |
decreased cardiac output |
decreased cardiac muscle contractility |
decreased ventricle muscle contractility |
abnormal heart echocardiography feature |
decreased heart rate |
prolonged RR interval |
abnormal impulse conducting system conduction |
prolonged PR interval |
prolonged P wave |
prolonged QRS complex duration |
sinoatrial block |
pulmonary hypertension |
abnormal vascular smooth muscle physiology |
abnormal vasodilation |
congestive heart failure |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||
| LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm1.1Bliu/Lmnatm1.1Bliu | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm1.1Otin/Lmnatm1.1Otin | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm1Gbon/Lmnatm1Gbon | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm2.1Gbon/Lmnatm2.1Gbon | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm2Stw/Lmnatm2Stw | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm3Stw/Lmnatm3Stw | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm5Lgf/Lmnatm5Lgf | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm8Lgf/Lmnatm8Lgf | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm12Lgf/Lmnatm12Lgf | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm1.1Bliu/Lmna+ | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm1.1Otin/Lmna+ | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm2.1Gbon/Lmna+ | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Lmnatm1Bliu/Lmna+ Tg(Tek-cre)1Ywa/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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