|
Symbol Name ID |
Flna
filamin, alpha MGI:95556 |
| Darker colors indicate more annotations |
| Human Phenotypes | Cerebral hemorrhage |
Right atrial enlargement |
Atrial septal defect |
Patent foramen ovale |
Abnormal cardiac septum morphology |
Cor pulmonale |
Abnormal heart valve morphology |
Bicuspid aortic valve |
Short chordae tendineae of the mitral valve |
Mitral valve prolapse |
Short chordae tendineae of the tricuspid valve |
Tricuspid valve prolapse |
Restrictive cardiomyopathy |
Aortic aneurysm |
Dilatation of the sinus of Valsalva |
Patent ductus arteriosus |
Stroke |
Systolic heart murmur |
Aortic regurgitation |
Aortic valve stenosis |
Mitral regurgitation |
Tricuspid regurgitation |
Pulmonary insufficiency |
Pulmonary arterial hypertension |
Congestive heart failure |
| Disease(s) Associated with FLNA | |||||||||||||||||||||||||
| craniosynostosis | |||||||||||||||||||||||||
| frontometaphyseal dysplasia 1 | |||||||||||||||||||||||||
| Melnick-Needles syndrome | |||||||||||||||||||||||||
| mitral valve prolapse | |||||||||||||||||||||||||
| otopalatodigital syndrome type 2 | |||||||||||||||||||||||||
| periventricular nodular heterotopia | |||||||||||||||||||||||||
| terminal osseous dysplasia | |||||||||||||||||||||||||
| X-linked cardiac valvular dysplasia | |||||||||||||||||||||||||
| X-linked chronic idiopathic intestinal pseudo-obstruction |
| Mouse Phenotypes | abnormal blood vessel morphology |
interrupted aortic arch |
abnormal vascular endothelial cell morphology |
abnormal intersomitic vessel morphology |
abnormal angiogenesis |
abnormal vascular regression |
abnormal cardiac outflow tract development |
persistent truncus arteriosus |
abnormal atrioventricular cushion morphology |
abnormal heart morphology |
double outlet right ventricle |
thick mitral valve |
atrial septal defect |
ostium primum atrial septal defect |
common ventricle |
ventricular septal defect |
decreased heart right ventricle size |
dilated heart |
hemorrhage |
abnormal vascular endothelial cell physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||||
| FlnaDilp2/Flna+ | |||||||||||||||||||||
| Flnatm1.2Caw/Flna+ | |||||||||||||||||||||
| FlnaDilp2/Y | |||||||||||||||||||||
| Flnatm1.2Caw/Y | |||||||||||||||||||||
| Flnatm1.1Caw/Y H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/21/2024 MGI 6.23 |
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