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Symbol
Name
ID
Calr
calreticulin
MGI:88252
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Bruising susceptibility
Purpura
Peripheral arterial stenosis
Abnormal cerebral vascular morphology
Ischemic stroke
Transient ischemic attack
Cerebral ischemia
Pulmonary arterial hypertension
Myocardial infarction
Syncope
Abnormal lymph node morphology
Abnormality of the spleen
Splenomegaly
Disease(s) Associated with CALR
Burkitt lymphoma
essential thrombocythemia
myelofibrosis

Mouse Phenotypes
increased cardiac muscle glycogen level
abnormal myocardial fiber morphology
abnormal intercalated disk morphology
decreased myocardial fiber number
trabecula carnea hypoplasia
thin myocardium compact layer
abnormal interventricular septum muscular part morphology
enlarged heart
small heart
dilated heart left ventricle
thin ventricular wall
cardiac interstitial fibrosis
dilated cardiomyopathy
decreased cardiac muscle contractility
abnormal heart echocardiography feature
prolonged PR interval
abnormal heart electrocardiography waveform feature
abnormal P wave
decreased QRS amplitude
abnormal T wave
increased cardiomyocyte apoptosis
ventricular cardiomyopathy
congestive heart failure
Availability Mouse Genotype
Calrtm1Mlk/Calrtm1Mlk
Calrtm1Star/Calrtm1Star
Tg(CAG-Calr)#Mlk/0
Tg(Myh6-cre/Esr1*)1Liao/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory