Symbol
Name
ID

Acvr1
activin A receptor, type 1
MGI:87911

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Iris hypoperfusion	Retinal vein occlusion
Disease(s) Associated with ACVR1	Iris hypoperfusion	Retinal vein occlusion
exfoliation syndrome

Mouse Phenotypes

cardiovascular system phenotype

abnormal pharyngeal arch artery morphology

abnormal sixth pharyngeal arch artery morphology

abnormal third pharyngeal arch artery morphology

abnormal aortic arch morphology

abnormal aortic arch and aortic arch branch attachment

retroesophageal right subclavian artery

abnormal brachiocephalic trunk morphology

abnormal vascular endothelial cell differentiation

abnormal cardiac epithelial to mesenchymal transition

decreased cardiac neural crest cell number

absent cardiac neural crest cells

impaired cardiac neural crest cell differentiation

abnormal cardiac outflow tract development

conotruncal ridge hypoplasia

persistent truncus arteriosus

abnormal atrioventricular cushion morphology

decreased atrioventricular cushion size

abnormal atrioventricular valve development

abnormal heart morphology

atrial septal defect

abnormal atrioventricular septum morphology

ventricular septal defect

enlarged heart

increased heart right ventricle size

cardiovascular shunt

Availability

Mouse Genotype

Acvr1^tm1Vk/Acvr1^tm1.1Vk
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Acvr1^tm1Vk/Acvr1^tm1.1Vk
Tg(Tek-cre)12Flv/0 (conditional)

Acvr1^tm1Vk/Acvr1^tm1.1Vk
Tg(Myh6-cre)2182Mds/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23