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Symbol
Name
ID 		Trex1
three prime repair exonuclease 1
MGI:1328317
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Hematemesis
Hematochezia
Retinal hemorrhage
Purpura
Petechiae
Cardiomyopathy
Hypertrophic cardiomyopathy
Pericardial effusion
Pericarditis
Cardiomegaly
Aortic aneurysm
Calcification of the aorta
Moyamoya phenomenon
Vasculitis
Vasculitis in the skin
Punctate vasculitis skin lesions
Stroke
Hypertension
Raynaud phenomenon
Abnormality of the hepatic vasculature
Lymphadenopathy
Generalized lymphadenopathy
Splenomegaly
Hepatosplenomegaly
Abnormal retinal vascular morphology
Retinal neovascularization
Cutis marmorata
Erythema
Telangiectasia
Urticaria
Disease(s) Associated with TREX1
Aicardi-Goutieres syndrome
Chilblain lupus
retinal vasculopathy with cerebral leukodystrophy
systemic lupus erythematosus

Mouse Phenotypes
liver vascular congestion
abnormal myocardial fiber morphology
myocardial fiber degeneration
abnormal heart morphology
dilated heart atrium
enlarged heart
dilated heart ventricle
cardiac fibrosis
vascular inflammation
cardiomyopathy
congestive heart failure
heart inflammation
myocarditis
Availability Mouse Genotype
Trex1tm1.1Fwpe/Trex1tm1.1Fwpe
Trex1tm1Tld/Trex1tm1Tld
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory