Symbol
Name
ID

Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
MGI:1206581

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Human Phenotypes	Abnormality of the cardiovascular system	Abnormal cardiovascular system morphology	Venous malformation	Splenomegaly
Disease(s) Associated with PIK3CA	Abnormality of the cardiovascular system	Abnormal cardiovascular system morphology	Venous malformation	Splenomegaly
CLOVES syndrome
Cowden syndrome 5

Mouse Phenotypes

abnormal blood vessel morphology

abnormal dorsal aorta morphology

abnormal brain vasculature morphology

abnormal retina vasculature morphology

abnormal intersomitic vessel morphology

abnormal vascular development

abnormal angiogenesis

abnormal anterior cardinal vein morphology

abnormal perineural vascular plexus morphology

abnormal vitelline vasculature morphology

abnormal vein morphology

blood vessel congestion

dilated vasculature

abnormal endocardium morphology

decreased heart weight

increased heart left ventricle size

thick ventricular wall

hemorrhage

internal hemorrhage

liver hemorrhage

decreased cardiac muscle contractility

abnormal myocardial fiber physiology

Availability

Mouse Genotype

Pik3ca^tm1Bvan/Pik3ca^tm1Bvan

Pik3ca^tm1Nbm/Pik3ca^tm1Nbm

Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺

Pik3ca^tm1Bvan/Pik3ca⁺

Pik3ca^tm1.1Rzl/Pik3ca^tm1.1Rzl
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (conditional)

Pik3ca^tm3Bvan/Pik3ca^tm3Bvan
Tg(Tek-cre)1Ywa/0 (conditional)

Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky}/Gt(ROSA)26Sor⁺
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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