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Symbol
Name
ID

Psen1
presenilin 1
MGI:1202717

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Left ventricular hypertrophy	Dilated cardiomyopathy	Severely reduced left ventricular ejection fraction	Increased left ventricular end-diastolic volume	First degree atrioventricular block	Left bundle branch block	Congestive heart failure	Syncope
Disease(s) Associated with PSEN1
dilated cardiomyopathy 1U

Mouse Phenotypes

cardiovascular system phenotype

abnormal blood vessel morphology

supravalvar pulmonary trunk stenosis

abnormal vascular endothelial cell morphology

abnormal capillary morphology

decreased capillary density

abnormal brain vasculature morphology

abnormal skin vasculature morphology

abnormal vascular development

abnormal angiogenesis

vascular stenosis

double outlet right ventricle

ventricular septal defect

hemorrhage

intracranial hemorrhage

intracerebral hemorrhage

intraventricular hemorrhage

spinal hemorrhage

increased vasodilation

Availability

Mouse Genotype

Psen1^{tm1.1(KOMP)Vlcg}/Psen1^{tm1.1(KOMP)Vlcg}

Psen1^tm1.1Tcs/Psen1^tm1.1Tcs

Psen1^tm1Bdes/Psen1^tm1Bdes

Psen1^tm1Hko/Psen1^tm1Hko

Psen1^tm1Pcw/Psen1^tm1Pcw

Psen1^tm1Shn/Psen1^tm1Shn

Psen1^tm1Shs/Psen1^tm1Shs

Psen1^tm2.1Shn/Psen1^tm2.1Shn

*

Psen1^tm1Mpm/Psen1^tm1Shn

Psen1^tm1Shn/Psen1^tm1.1Tcs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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