Symbol
Name
ID

Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335

Phenotype annotations related to cardiovascular system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal blood vessel morphology

abnormal brain vasculature morphology

abnormal lung vasculature morphology

abnormal myocardium layer morphology

increased myocardial fiber size

abnormal myocardial trabeculae morphology

abnormal trabecula carnea morphology

thin myocardium

abnormal atrioventricular valve morphology

abnormal mitral valve cusp morphology

abnormal tricuspid valve morphology

thick tricuspid valve cusps

enlarged atrioventricular valve

ventricular septal defect

increased heart weight

enlarged heart

abnormal heart valve morphology

abnormal semilunar valve morphology

abnormal aortic valve morphology

abnormal aortic valve cusp morphology

thick aortic valve cusps

aortic valve stenosis

enlarged aortic valve

aortic valve hypertrophy

thick aortic valve

abnormal pulmonary valve morphology

thick pulmonary valve cusps

enlarged pulmonary valve

pulmonary valve hypertrophy

thick pulmonary valve

enlarged semilunar valve

increased heart left ventricle weight

increased heart left ventricle size

increased heart ventricle size

thick ventricular wall

internal hemorrhage

decreased cardiac muscle contractility

abnormal fetal cardiomyocyte proliferation

abnormal aortic valve flow

increased heart rate

pathological neovascularization

Availability

Mouse Genotype

Adam17^tm1.1Bbl/Adam17^tm1.1Bbl

Adam17^tm1.1Srj/Adam17^tm1.1Srj

Adam17^tm1.2Rain/Adam17^tm1.2Rain

Adam17^tm1.2Wesh/Adam17^tm1.2Wesh

Adam17^tm1Imx/Adam17^tm1Imx

Adam17^woe/Adam17^woe

Adam17^tm1.1Wesh/Adam17^tm1.1Wesh
Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ (conditional)

Adam17^tm1.1Wesh/Adam17^tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0 (conditional)

Adam17^tm1.1Wesh/Adam17^tm1.1Wesh
Tg(Scgb1a1-rtTA)2Jaw/0
Tg(tetO-cre)1Jaw/0
Twist2^{tm1.1(cre)Dor}/Twist2⁺ (conditional)

Adam17^tm1.1Rain/Adam17^tm1.2Rain
Tg(Tek-cre)12Flv/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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