|
Symbol Name ID |
Pten
phosphatase and tensin homolog MGI:109583 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Intracranial hemorrhage |
Subcutaneous hemorrhage |
Aortic aneurysm |
Arteriovenous malformation |
Dilation of Virchow-Robin spaces |
Angina pectoris |
Abnormality of the vasculature |
Splenomegaly |
Capillary hemangioma |
Visceral angiomatosis |
Cutis marmorata |
Telangiectasia |
| Disease(s) Associated with PTEN | ||||||||||||
| Bannayan-Riley-Ruvalcaba syndrome | ||||||||||||
| macrocephaly-autism syndrome |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal glomerular capillary morphology |
abnormal brain vasculature morphology |
abnormal liver sinusoid morphology |
abnormal lung vasculature morphology |
abnormal placenta vasculature |
abnormal vascular development |
increased myocardial fiber mitochondrial DNA content |
increased myocardial fiber size |
cardia bifida |
abnormal pericardium development |
abnormal heart morphology |
enlarged heart |
cardiac hypertrophy |
abnormal heart left ventricle morphology |
hemorrhage |
decreased cardiac muscle contractility |
abnormal response to cardiac infarction |
decreased myocardial infarct size |
increased susceptibility to myocardial ischemic injury |
increased myocardial infarct size |
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| Availability | Mouse Genotype | |||||||||||||||||||||
| Ptenm1un/Ptenm1un | ||||||||||||||||||||||
| Ptentm1.1Hwu/Ptentm1.1Hwu | ||||||||||||||||||||||
| Ptentm1.1Yxy/Ptentm1.1Yxy | * | |||||||||||||||||||||
| Ptentm1.1Hwu/Pten+ | ||||||||||||||||||||||
| Ptentm1Hwu/Ptentm1Hwu A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ (conditional) |
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| Amhr2tm3(cre)Bhr/Amhr2+ Ptentm1Hwu/Ptentm1Hwu (conditional) |
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| Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ (conditional) |
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| Ptentm2Mak/Ptentm2Mak Tg(Ckmm-cre)5Khn/0 (conditional) |
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| Ptentm2Mak/Ptentm2Mak Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ptentm2Mak/Ptentm2Mak Tg(Hoxb7-cre)5526Cmb/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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