Symbol
Name
ID

Pros1
protein S (alpha)
MGI:1095733

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cerebral hemorrhage	Subcutaneous hemorrhage	Purpura	Venous insufficiency	Abnormal cerebral vascular morphology	Stroke	Pulmonary embolism
Disease(s) Associated with PROS1	Cerebral hemorrhage	Subcutaneous hemorrhage	Purpura	Venous insufficiency	Abnormal cerebral vascular morphology	Stroke	Pulmonary embolism
autosomal dominant thrombophilia due to protein S deficiency
autosomal recessive thrombophilia due to protein S deficiency
cerebral infarction

Mouse Phenotypes

cardiovascular system phenotype

abnormal blood vessel morphology

abnormal brain vasculature morphology

brain vascular congestion

abnormal vitelline vasculature morphology

vascular smooth muscle hypoplasia

blood vessel congestion

bruising

hemorrhage

intracranial hemorrhage

increased vascular permeability

Availability

Mouse Genotype

Pros1^tm1.1Ansc/Pros1^tm1.1Ansc

Pros1^tm1.2Grl/Pros1^tm1.2Grl

Pros1^tm1.2Grl/Pros1⁺

Pros1^tm1Grl/Pros1^tm1Grl
Tg(Tek-cre)1Ywa/0 (conditional)

Pros1^tm1Grl/Pros1^tm1Grl
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Pros1^tm1Grl/Pros1^tm1Grl
Tg(Tagln-cre)1Her/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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