Symbol
Name
ID

Jag1
jagged 1
MGI:1095416

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Atrial septal defect	Ventricular septal defect	Tetralogy of Fallot	Coarctation of aorta	Peripheral pulmonary artery stenosis	Renal artery stenosis	Stroke	Pulmonic stenosis	Hypertension	Telangiectasia of the skin
Disease(s) Associated with JAG1	Atrial septal defect	Ventricular septal defect	Tetralogy of Fallot	Coarctation of aorta	Peripheral pulmonary artery stenosis	Renal artery stenosis	Stroke	Pulmonic stenosis	Hypertension	Telangiectasia of the skin
Alagille syndrome
tetralogy of Fallot

Mouse Phenotypes

cardiovascular system phenotype

abnormal blood vessel morphology

abnormal pulmonary trunk morphology

abnormal aorta morphology

retroesophageal right subclavian artery

abnormal retina vasculature morphology

abnormal liver vasculature morphology

abnormal vascular development

abnormal angiogenesis

patent ductus arteriosus

abnormal vascular branching morphogenesis

decreased angiogenesis

abnormal vitelline vasculature morphology

abnormal vascular smooth muscle morphology

heart right ventricle hypertrophy

abnormal cardiac outflow tract development

abnormal heart morphology

abnormal coronary vessel morphology

overriding aortic valve

increased heart right atrium size

atrial septal defect

ventricular septal defect

abnormal heart valve morphology

calcified aortic valve

pulmonary valve stenosis

thick heart valve cusps

increased heart right ventricle size

increased heart right ventricle wall thickness

pericardial edema

distended pericardium

enlarged pericardium

dilated heart

hemorrhage

intracranial hemorrhage

liver hemorrhage

pulmonary valve regurgitation

increased systemic arterial systolic blood pressure

Availability

Mouse Genotype

Jag1^Mhdahtu/Jag1^Mhdahtu

Jag1^Ndr/Jag1^Ndr

Jag1^Slalom/Jag1^Slalom

Jag1^tm1Grid/Jag1^tm1Grid

Jag1^tm2.1Grid/Jag1^tm2.1Grid

Jag1^Mhdahtu/Jag1^Slalom

Jag1^tm1Frad/Jag1^tm1Frad
Tg(Tagln-cre)1Her/0 (conditional)

Jag1^tm1Frad/Jag1^tm1Frad
Tg(Cdh5-cre)7Mlia/0 (conditional)

Jag1^tm1Jlew/Jag1^tm1Jlew
Tg(Tie1-cre)9Ref/0 (conditional)

Jag1^tm1Jlew/Jag1^tm1Jlew
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 (conditional)

Jag1^tm2Grid/Jag1^tm2Grid
Tg(Tek-cre)12Flv/0 (conditional)

Jag1^tm2Grid/Jag1^tm2Grid
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Jag1^tm1Grid/Jag1^tm2Grid
Tg(Tagln-cre)1Her/0 (conditional)

Jag1^tm1Jlew/Jag1^tm1Grid
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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