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Symbol
Name
ID
Zic3
zinc finger protein of the cerebellum 3
MGI:106676
Phenotype annotations related to cardiovascular system
Darker colors indicate more annotations
Human Phenotypes
Abnormal cardiovascular system morphology
Dextrocardia
Situs inversus totalis
Mesocardia
Left atrial isomerism
Right atrial isomerism
Atrial septal defect
Patent foramen ovale
Common atrium
Ventricular septal defect
Atrioventricular canal defect
Complete atrioventricular canal defect
Unbalanced atrioventricular canal defect
Subvalvular aortic stenosis
Single ventricle
Double inlet left ventricle
Mitral atresia
Double outlet right ventricle
Transposition of the great arteries
Dextrotransposition of the great arteries
Cardiomegaly
Hypoplastic left heart
Right aortic arch
Hypoplastic aortic arch
Ascending tubular aorta aneurysm
Coarctation of aorta
Pulmonary artery atresia
Partial anomalous pulmonary venous return
Total anomalous pulmonary venous return
Interrupted inferior vena cava with azygous continuation
Persistent left superior vena cava
Bilateral superior vena cava
Left superior vena cava draining to coronary sinus
Patent ductus arteriosus
Mitral stenosis
Pulmonic stenosis
Atrial reentry tachycardia
Asplenia
Ectopia of the spleen
Polysplenia
Disease(s) Associated with ZIC3
situs inversus
visceral heterotaxy
X-linked VACTERL association

Mouse Phenotypes
abnormal cardiovascular system morphology
interrupted aortic arch
right aortic arch
abnormal inferior vena cava morphology
abnormal heart development
abnormal heart looping
abnormal direction of heart looping
abnormal heart morphology
double outlet right ventricle
d-loop transposition of the great arteries
atrial septal defect
abnormal heart position or orientation
dextrocardia
ectopia cordis
ventricular septal defect
Availability Mouse Genotype
Zic3Ka/Zic3Ka
Zic3tm1Bca/Zic3tm1Bca
Zic3tm1Jwb/Zic3tm1Jwb
Zic3tm1Bca/Zic3+
Zic3Ka/Y
Zic3tm1Bca/Y
Zic3tm1Jwb/Y
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+  (conditional)
Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+  (conditional)
Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0  (conditional)
Zic3tm2.1Jwb/Y
Tg(T-cre)1Lwd/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory