|
Symbol Name ID |
Tbx5
T-box 5 MGI:102541 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal cardiovascular system morphology |
Atrial septal defect |
Patent foramen ovale |
Secundum atrial septal defect |
Sinus venosus atrial septal defect |
Cor triatrium sinister |
Ventricular septal defect |
Muscular ventricular septal defect |
Perimembranous ventricular septal defect |
Atrioventricular canal defect |
Complete atrioventricular canal defect |
Hypoplasia of right ventricle |
Double outlet right ventricle |
Mitral valve prolapse |
Tricuspid valve prolapse |
Left ventricular noncompaction cardiomyopathy |
Hypoplastic left heart |
Abnormal aortic morphology |
Anomalous pulmonary venous return |
Persistent left superior vena cava |
Patent ductus arteriosus |
Abnormal coronary artery origin |
Mitral regurgitation |
Tricuspid regurgitation |
Pulmonic stenosis |
Pulmonary arterial hypertension |
Sinus bradycardia |
Paroxysmal atrial fibrillation |
Ventricular tachycardia |
Atrioventricular block |
First degree atrioventricular block |
Atrioventricular dissociation |
| Disease(s) Associated with TBX5 | ||||||||||||||||||||||||||||||||
| Holt-Oram syndrome |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal impulse conducting system morphology |
abnormal atrioventricular bundle morphology |
abnormal left posterior bundle morphology |
abnormal right bundle morphology |
abnormal heart development |
absent atrioventricular cushions |
failure of heart looping |
abnormal heart tube morphology |
abnormal heart morphology |
abnormal heart atrium morphology |
heart atrium hypoplasia |
atrial septal defect |
common atrium |
ostium primum atrial septal defect |
dilated heart atrium |
perimembraneous ventricular septal defect |
muscular ventricular septal defect |
ventricular septal defect |
abnormal heart ventricle shape |
enlarged heart |
abnormal heart left ventricle morphology |
pericardial effusion |
abnormal cardiovascular system physiology |
abnormal sinus arrhythmia |
ventricular tachycardia |
irregular heartbeat |
ventricular premature beat |
abnormal impulse conducting system conduction |
abnormal atrioventricular bundle conduction |
abnormal atrioventricular node conduction |
prolonged PR interval |
atrioventricular block |
prolonged P wave |
prolonged PQ interval |
prolonged QRS complex duration |
abnormal sinoatrial node conduction |
sinoatrial block |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||
| Tbx5tm1.1Jse/Tbx5tm1.1Jse | |||||||||||||||||||||||||||||||||||||||
| Tbx5tm1Jse/Tbx5tm1Jse | |||||||||||||||||||||||||||||||||||||||
| Tbx5tm1.1Jse/Tbx5+ | |||||||||||||||||||||||||||||||||||||||
| Tbx5tm1Jse/Tbx5+ | |||||||||||||||||||||||||||||||||||||||
| Tbx5tm1.2Jse/Tbx5tm1.2Jse Tg(Kcne1-cre/ERT2)1Imos/0 (conditional) |
* | ||||||||||||||||||||||||||||||||||||||
| Tbx5tm1.2Jse/Tbx5tm1.2Jse (conditional) | |||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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