Symbol
Name
ID

Grn
granulin
MGI:95832

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Depression

Emotional lability

Atypical behavior

Diminished motivation

Apathy

Abnormal sexual behavior

Hypersexuality

Inappropriate laughter

Personality changes

Polyphagia

Disinhibition

Agitation

Repetitive compulsive behavior

Hyperorality

Fatigue

Pain

Disease(s) Associated with GRN

amyotrophic lateral sclerosis

frontotemporal dementia

Grn-related frontotemporal lobar degeneration with Tdp43 inclusions

Mouse Phenotypes

behavior/neurological phenotype

impaired contextual conditioning behavior

abnormal spatial learning

impaired spatial learning

abnormal long-term spatial reference memory

increased fluid intake

polydipsia

increased food intake

decreased aggression towards male mice

increased aggression towards male mice

increased anxiety-related response

increased thigmotaxis

abnormal response to novel object

decreased grooming behavior

increased grooming behavior

impaired coordination

abnormal social investigation

Availability

Mouse Genotype

Grn^tm1.1Aidi/Grn^tm1.1Aidi

Grn^tm1.1Geno/Grn^tm1.1Geno

Grn^tm1Blrl/Grn^tm1Blrl

Grn^tm1Mni/Grn^tm1Mni

Grn^tm2.1Far/Grn^tm2.1Far

Grn^tm1.1Hiok/Grn⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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