Symbol
Name
ID

Ctnnb1
catenin beta 1
MGI:88276

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Feeding difficulties	Back pain	Lethargy	Autistic behavior	Aggressive behavior	Restlessness	Self-mutilation
Disease(s) Associated with CTNNB1	Feeding difficulties	Back pain	Lethargy	Autistic behavior	Aggressive behavior	Restlessness	Self-mutilation
autosomal dominant intellectual developmental disorder 19
medulloblastoma

Mouse Phenotypes

behavior/neurological phenotype

increased susceptibility to pharmacologically induced seizures

impaired contextual conditioning behavior

abnormal operant conditioning behavior

impaired long-term object recognition memory

enhanced spatial learning

abnormal spatial reference memory

abnormal suckling behavior

increased anxiety-related response

increased thigmotaxis

slow extinction of fear memory

abnormal response to social novelty

increased grooming behavior

impaired coordination

abnormal head movements

stereotypic behavior

abnormal nursing

abnormal nest building behavior

abnormal vocalization

seizures

Availability

Mouse Genotype

Ctnnb1^Bfc/Ctnnb1⁺

Ctnnb1^tm2Kem/Ctnnb1^tm2Kem
Emx1^tm1(cre)Yql/Emx1⁺ (conditional)

Ctnnb1^tm2Kem/Ctnnb1^tm2Kem
Pvalb^tm1(cre)Arbr/Pvalb⁺ (conditional)

Ctnnb1^tm1Max/Ctnnb1^tm2Kem
Tg(Msx2-cre)5Rem/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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