Symbol
Name
ID

Nlgn3
neuroligin 3
MGI:2444609

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Lack of spontaneous play	Impaired ability to form peer relationships	Autism	Inflexible adherence to routines	Motor stereotypy	Restrictive behavior
Disease(s) Associated with NLGN3
autistic disorder

Mouse Phenotypes

behavior/neurological phenotype

abnormal learning/memory/conditioning

impaired contextual conditioning behavior

impaired cued conditioning behavior

increased exploration in new environment

abnormal spatial learning

enhanced learning

decreased anxiety-related response

increased thigmotaxis

abnormal righting response

decreased startle reflex

abnormal motor coordination/balance

enhanced coordination

impaired coordination

abnormal locomotor activation

decreased vertical activity

increased vertical activity

decreased locomotor activity

increased locomotor activity

hyperactivity

stereotypic behavior

increased stereotypic behavior

abnormal social investigation

decreased vocalization

Availability

Mouse Genotype

Nlgn3^{em1(IMPC)Rbrc}/Nlgn3^{em1(IMPC)Rbrc}

Nlgn3^tm1.1Htz/Nlgn3^tm1.1Htz

Nlgn3^tm1Bros/Nlgn3^tm1Bros

Nlgn3^{em1(IMPC)Rbrc}/Y

Nlgn3^tm1.1Htz/Y

Nlgn3^tm1Rhn/Y

Nlgn3^tm1Sud/Y

Nlgn3^tm2.1Sud/Y

Nlgn3^tm4.1Sud/Y
Pvalb^tm1(cre)Arbr/Pvalb⁺ (conditional)

Nlgn3^tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0 (conditional)

Nlgn3^tm4.1Sud/Y
Tg(Nes-cre)1Kln/0 (conditional)

Nlgn3^tm4.1Sud/Y
Tg(Pcp2-cre)2Mpin/0 (conditional)

Nlgn3^tm4.1Sud/Y
Tg(Drd1-cre)EY262Gsat/0 (conditional)

Nlgn3^tm4.1Sud/Y
Tg(Adora2a-cre)2MDkde/0 (conditional)

Nlgn3^tm4.1Sud/Y (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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