Phenotypes associated with Htr2a<tm1Grch>/Htr2a<tm2Grch>

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Phenotypes associated with Htr2a^tm1Grch/Htr2a^tm2Grch

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Htr2a^tm1Grch/Htr2a^tm2Grch	involves: 129S6/SvEvTac	MGI:3663443
ht2	Htr2a^tm1Grch/Htr2a^tm2Grch	129S6/SvEv-Htr2a^tm1Grch Htr2a^tm2Grch	MGI:3663440

Comparison Matrix Gene Expression + Phenotype

Allelic Composition	Htr2a^tm1Grch/Htr2a^tm2Grch
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2a^tm1Grch mutation (0 available); any Htr2a mutation (43 available)
Htr2a^tm2Grch mutation (0 available); any Htr2a mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:110958 )

• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test

Allelic Composition	Htr2a^tm1Grch/Htr2a^tm2Grch
Genetic Background	129S6/SvEv-Htr2a^tm1Grch Htr2a^tm2Grch

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:110958 )

• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors

• home cage activity did not differ

• motor coordination, strength, and sensory processing were unimpaired

• baseline concentrations and the rise in corticosterone release following anxiety tests were comparable

• cell number, mantel thickness, barrel field formation, or the expression of GABA containing neuronal markers are normal

decreased anxiety-related response ( J:110958 )

• explored the lit compartment to a greater extent in the dark-light choice test

• explored the riskier portions of the elevated plus-maze to a greater extent

• exhibited a shorter latency to begin feeding in a novel environment

increased vertical activity ( J:110958 )

• in open field

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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