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All mouse models of sarcoma with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | osteosarcoma |
Prkar1atm1.2Lsk/Prkar1a+ Rb1tm2Brn/Rb1+ Tg(Col1a1-cre)1Kry/0 Trp53tm1Brn/Trp53tm1Brn |
involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N | J:234128 | View | |||
| osteosarcoma |
Prkar1atm1.2Lsk/Prkar1a+ Rb1tm2Brn/Rb1tm2Brn Trp53tm1Brn/Trp53tm1Brn Tg(Col1a1-cre)1Kry/0 |
involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N | J:234128 | View | ||||
| osteosarcoma |
Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N | J:234128 | View | ||||
| osteosarcoma |
Ptch1tm1Yy/Ptch1+ Trp53tm1Brd/Trp53+ Tg(BGLAP-cre)1Clem/0 |
involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ | J:214349 | View | ||||
| osteosarcoma |
Rb1tm3Tyj/Rb1+ Trp53tm1Brn/Trp53tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CD-1 * FVB/N | J:136693 | View | ||||
| osteosarcoma |
Rb1tm3Tyj/Rb1tm3Tyj Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Tg(tetO-RNAi:Trp53)ASlowe/0 |
involves: 129S4/SvJae * C57BL/6 * CD-1 | J:199542 | View | ||||
| osteosarcoma |
Rb1tm3Tyj/Rb1tm3Tyj Trp53tm1Brn/Trp53tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1 | J:199542 | View | ||||
| osteosarcoma |
Rb1tm3Tyj/Rb1tm3Tyj Trp53tm1Brn/Trp53tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CD-1 * FVB/N | J:136693, J:318035 | View | ||||
| osteosarcoma |
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Tg(tetO-RNAi:Trp53)ASlowe/0 |
involves: C57BL/6 * CD-1 | J:199542 | View | ||||
| osteosarcoma |
Trp53tm1Brn/Trp53tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 | J:199542 | View | ||||
| | alveolar rhabdomyosarcoma |
Cdkn2atm4Rdp/Cdkn2atm4Rdp Myf6tm1(cre)Mrc/Myf6+ Pax3tm1Mrc/Pax3tm1Mrc |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:93444 | View | |||
| alveolar rhabdomyosarcoma |
Myf6tm1(cre)Mrc/Myf6+ Pax3tm1Mrc/Pax3+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:93444 | View | ||||
| alveolar rhabdomyosarcoma |
Myf6tm1(cre)Mrc/Myf6+ Pax3tm1Mrc/Pax3tm1Mrc Trp53tm1Brn/Trp53+ |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:93444 | View | ||||
| alveolar rhabdomyosarcoma |
Myf6tm1(cre)Mrc/Myf6+ Pax3tm1Mrc/Pax3tm1Mrc Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL | J:93444 | View | ||||
| sarcoma |
Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 | J:125101, J:155389, J:204376 | View | ||||
| Transgenes and Other Mutations | osteosarcoma | Tg(Bglap2-TAg)1Rkho/0 | FVB/N-Tg(Bglap2-TAg)1Rkho | J:165282 | View | |||
| osteosarcoma | Tg(Bglap2-TAg)1Rkho/0 | involves: FVB/N | J:234128 | View | ||||
| Additional Complex Models | clear cell sarcoma |
Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+ Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ |
involves: 129S4/SvJae * C57BL/6 | J:194505 | View | |||
| embryonal rhabdomyosarcoma |
Cdkn2atm1Cjs/Cdkn2atm1Cjs Tg(CKMM-tTA)A3Rhvh/0 Tg(tetO-Hgf,-EGFP)24Tcre/0 |
involves: 129X1/SvJ * FVB | J:237183 | View | ||||
| malignant fibrous histiocytoma |
Krastm4Tyj/Kras+ Trp53tm1Brn/Trp53tm1Brn |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 | J:155389 | View | ||||
| rhabdomyosarcoma |
Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(Mt1-Hgf)19Lmb/0 |
involves: 129/Sv * C57BL/6J * FVB/N * SJL | J:79704 | View | ||||
| sarcoma |
Cdkn2atm4Rdp/Cdkn2atm4Rdp Krastm4Tyj/Kras+ |
involves: 129S4/SvJae * C57BL/6 | J:125101 | View | ||||
| sarcoma |
Cdkn2atm4Rdp/Cdkn2atm4Rdp Nf1tm1Par/Nf1tm1Par |
involves: 129S1/Sv * 129X1/SvJ | J:234760 | View | ||||