Phenotypes for Col1a1 Gt(ROSA)26Sor MGI:5485198 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Col1a1^{tm1(tetO-EWSR1/ATF1)Yasu}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(tetO-EWSR1/ATF1)Yasu} mutation (0 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (32 available); any Gt(ROSA)26Sor mutation (1046 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:194505 )

• after 3 to 10 months of doxycycline-treated mice with median survival of 20 weeks

neoplasm

tumor regression ( J:194505 )

• in doxycycline-treated mice following withdrawal of doxycycline

increased sarcoma incidence ( J:194505 )

• in the trunks, heads, limbs, and whisker pads of all doxycycline-treated mice after 3 months arising from neural crest-lineage cells

cellular

decreased fibroblast proliferation ( J:194505 )

• in doxycycline-treated mouse embryonic fibroblasts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
clear cell sarcoma		DOID:4233		J:194505

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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