Phenotypes Associated with This Genotype

Genotype
MGI:5796170

• Allelic Composition: Tg(Bglap2-TAg)1Rkho/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:234128 )

• 50% of mice survive to 26 weeks of age

neoplasm

increased osteosarcoma incidence ( J:234128 )

• mice develop aggressive osteosarcoma with complete penetrance

• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold

skeleton

increased osteosarcoma incidence ( J:234128 )

• mice develop aggressive osteosarcoma with complete penetrance

• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteosarcoma		DOID:3347	OMIM:259500	J:234128