tetanus (DOID:11338)
Alliance: disease page
Synonyms: clostridial tetanus; Infection due to Clostridium tetani
Alt IDs: ICD10CM:A35, ICD9CM:037, MESH:D013742, NCI:C85185, UMLS_CUI:C0039614
Definition: A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.