hereditary combined deficiency of vitamin K-dependent clotting factors (DOID:0112172)
Alliance: disease page
Synonyms: hereditary combined deficiency of factors II, VII, IX and X; VKCFD
Alt IDs: ORDO:98434, UMLS_CUI:C4510617
Definition: A blood coagulation disease characterized by reduced hepatic gamma-carboxylation of glutamic acid residues of all vitamin K-dependent blood coagulation factors and the anticoagulant factors protein C and protein S resulting in a bleeding tendency that is usually reversed by oral administration of vitamin K that has_material_basis_in a heritable mutation.