core binding factor acute myeloid leukemia (DOID:0080796)
Alliance: disease page
Alt IDs: NCI:C122688
Definition: An acute myeloid leukemia that is characterized by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). These cytogenetic abnormalities result in disruption of the transcription factor CBF, which is a regulator of normal hematopoiesis.