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Disease Ontology Browser
diffuse midline glioma, H3 K27-altered (DOID:0080684)
Alliance: disease page
Synonyms: diffuse intrinsic pontine glioma; diffuse midline glioma, H3 K27M-mutant
Alt IDs: ICD10CM:C71.9, NCI:C185368, ORDO:723358, UMLS_CUI:C5669877
Definition: A histone mutated tumor that is characterized by loss of histone H3 p.K28me3 (K27me3) methylation and located throughout the midline structures of the central nervous system. Methylation loss may be due to p.K28M (K27M) mutation in one of the histone H3 isoforms (H3.1, H3.2, or H3.3), overexpression of EZHIP, or mutation of the EGFR gene.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/09/2026
MGI 6.24 		The Jackson Laboratory