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Disease Ontology Browser
infection-induced acute-onset axonal neuropathy (DOID:0070798)
Alliance: disease page
Synonyms: IIAAN
Alt IDs: OMIM:621333, UMLS_CUI:C6065907
Definition: A motor neuron disease characterized by acute onset of progressive muscle weakness and axonal sensorimotor neuropathy following an infection or febrile episode in infancy or early childhood that has_material_basis_in homozygous or compound heterozygous mutation in the RCC1 gene on chromosome 1p35. Affected individuals may have progressive cerebral and cerebellar atrophy and may have recurrent episodes resulting in loss of ambulation, long-term ventilatory support, or early death.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory