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Disease Ontology Browser
spermatogenic failure 99 (DOID:0070728)
Alliance: disease page
Synonyms: SPGF99
Alt IDs: OMIM:621194
Definition: A spermatogenic failure characterized by male infertility due to asthenoteratozoospermia with severely reduced sperm progressive motility, sperm with a thin midpiece, absence of the annulus, and disorganization of the mitochondrial sheath that has_material_basis_in homozygous mutation in the SEPTIN4 gene (603696) on chromosome 17q22.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/26/2026
MGI 6.24 		The Jackson Laboratory