Gene Expression Data
Assay Details
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Assay
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Reference:
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J:392011
Hiatt SM, et al., Monoallelic loss-of-function variants in ZNF536 are associated with a neurodevelopmental disorder with prominent behavioral features. Am J Hum Genet. 2026 Sep 4;
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:8434039
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Gene symbol:
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Tbr1
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Gene name:
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T-box brain transcription factor 1
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Results
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Specimen
4E TBR1 WT:
embryonic day 18.5
(more  )
Specimen
4E TBR1 WT:
(close  )
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Genetic Background:
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involves: C57BL/6J
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
4E TBR1 HET:
embryonic day 18.5; Zfp536em1Wjz/Zfp536 +
(more )
Specimen
4E TBR1 HET:
(close )
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Genetic Background:
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involves: C57BL/6J
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Mutant Allele(s):
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Zfp536em1Wjz/Zfp536+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cerebral cortex |
Present |
Regionally restricted |
4E TBR1 HET
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Thickness of layer of expressing cells largely unchanged compared to wild type.
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Specimen
4E TBR1 HOM:
(close )
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Genetic Background:
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involves: C57BL/6J
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Mutant Allele(s):
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Zfp536em1Wjz/Zfp536em1Wjz
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cerebral cortex |
Present |
Regionally restricted |
4E TBR1 HOM
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Thickness of layer of expressing cells largely unchanged compared to wild type.
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Specimen
4G TBR1 WT:
embryonic day 18.5
(more )
Specimen
4G TBR1 WT:
(close )
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Genetic Background:
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involves: C57BL/6J
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Age:
|
embryonic day 18.5
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
4G TBR1 HET:
embryonic day 18.5; Zfp536em1Wjz/Zfp536 +
(more )
Specimen
4G TBR1 HET:
(close )
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Genetic Background:
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involves: C57BL/6J
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Mutant Allele(s):
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Zfp536em1Wjz/Zfp536+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cerebral cortex |
Present |
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4G TBR1 HET
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Density of expressing neurons reduced compared to wild type
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Specimen
4G TBR1 HOM:
(close )
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Genetic Background:
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involves: C57BL/6J
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Mutant Allele(s):
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Zfp536em1Wjz/Zfp536em1Wjz
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
|
| Structure |
Level |
Pattern |
Image |
Note |
| TS26: cerebral cortex |
Present |
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4G TBR1 HOM
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Density of expressing neurons reduced compared to wild type
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Specimen
S4C TBR1 WT:
postnatal adult
(more )
Specimen
S4C TBR1 WT:
(close )
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Genetic Background:
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involves: C57BL/6J
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
S4C TBR1 HET:
postnatal adult; Zfp536em1Wjz/Zfp536 +
(more )
Specimen
S4C TBR1 HET:
(close )
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Genetic Background:
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involves: C57BL/6J
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Mutant Allele(s):
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Zfp536em1Wjz/Zfp536+
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
S4E TBR1 WT:
postnatal adult
(more )
Specimen
S4E TBR1 WT:
(close )
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Genetic Background:
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involves: C57BL/6J
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Specimen
S4E TBR1 HET:
postnatal adult; Zfp536em1Wjz/Zfp536 +
(more )
Specimen
S4E TBR1 HET:
(close )
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Genetic Background:
|
involves: C57BL/6J
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Mutant Allele(s):
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Zfp536em1Wjz/Zfp536+
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Age:
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postnatal adult
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Sex:
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Not Specified
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Type:
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optical section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Cryosection
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Analysis Tools