Pdx1 Immunohistochemistry Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:279716 Braitsch CM, et al., LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
Assay type:	Immunohistochemistry
MGI Accession ID:	MGI:8351673
Gene symbol:	Pdx1
Gene name:	pancreatic and duodenal homeobox 1

Antibody:	anti-Pdx1 (clone F6A11)
Detection system:	Secondary antibody coupled to Alexa Fluor

Results

S2B WT ©

Specimen S2B WT: embryonic day 12.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S2B WT

Specimen S2B Lats1/2/Yap1^PanKOTaz^Het: embryonic day 12.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0, Wwtr1^tm1.1Eno/Wwtr1⁺, Yap1^tm1.1Eno/Yap1^tm1.1Eno (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS20: pancreas	Present		S2B Lats1/2/Yap1^PanKOTaz^Het	Normal expression was detected in Lats1/2/Yap1<PanKO>Taz<Het> mice.

Specimen S2B Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: pancreas	Ambiguous		S2B Lats1/2^PanKO

S3A WT upper ©

Specimen S3A WT: embryonic day 10.75 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present	Regionally restricted	S3A WT upper	Expression was detected in epithelium.

Specimen S3A Lats1/2^PanKO: embryonic day 10.75; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present	Regionally restricted	S3A Lats1/2^PanKO upper	No significant difference in the relative percentage of immunopositive epithelial cells was found between WT and mutant tissue at E10.75.

S3D WT upper ©

Specimen S3D WT: embryonic day 13.5 (more

)
Note: Controls were either wild type or heterozygous littermates.

Structure	Level	Pattern	Image	Note
TS21: pancreas epithelium	Present		S3D WT upper

Specimen S3D Lats1/2^PanKO: embryonic day 13.5; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: pancreas epithelium	Ambiguous		S3D Lats1/2^PanKO upper	Expression was decreased in Lats1/2<PanKO> pancreas.

S9C WT row 1 ©

Specimen S9C WT: embryonic day 10.75 (more

)
Note: Controls were either wild type or heterozygous littermates. Double labeled: green - Pdx1; red - pHH3.

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present	Regionally restricted	S9C WT row 1	Expression was detected in epithelium.

Specimen S9C Lats1/2^PanKO: embryonic day 10.75; Lats1^tm1.1Jfm/Lats1^tm1.1Jfm, Lats2^tm1.1Jfm/Lats2^tm1.1Jfm, Tg(Pdx1-cre)89.1Dam/0 (more

)
Note: Conditional mutant. Double labeled: green - Pdx1; red - pHH3.

Structure	Level	Pattern	Image	Note
TS17: pancreas primordium	Present	Regionally restricted	S9C Lats1/2^PanKO row 1	No significant difference in the relative percentage of immunopositive epithelial cells was found between WT and mutant tissue at E10.75.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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