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Gene Expression Data
Assay Details
Assay
Reference: J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8270657
Gene symbol: Ebf1
Gene name: early B cell factor 1
Antibody: anti-EBF1 (AB10523)
Detection system: Secondary antibody coupled to Alexa Fluor
Assay notes: Nolz1-/- mutant embryos, in which the coding region of Nolz1 has been replaced by beta-Galactosidase (also referred to as Nolz1<bgal/bgal>). Zfp503<tm1.1Bpb> (neo cassette removed) has been used in the annotations, but it could be Zfp503<tm1Bpb> (neo cassette still present).
Results
Specimen 4a WT: embryonic day 11.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: corpus striatum striatum neuron Present Regionally restricted 4a WT EBF1 Expression is in striatonigral neurons.
Specimen 4a Nolz1-/-: embryonic day 11.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Structure Level Pattern Image Note
TS20: corpus striatum Absent 4a Nolz1-/- EBF1
Specimen S4a E10.5 injected: embryonic day 15.5 (more )
Note: Double labeled: red - Ebf1; green - BrdU injected at E10.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted S4a E10.5 injected boxed area , S4a E10.5 injected Expression is in striatonigral neurons.
Specimen S4a E11.5 injected: embryonic day 15.5 (more )
Note: Double labeled: red - Ebf1; green - BrdU injected at E11.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted S4a E11.5 injected boxed area , S4a E11.5 injected Expression is in striatonigral neurons. The majority of neurons born in wild type embryos at E11.5 (e.g. BrdU+) are positive for the striatonigral specific marker EBF1.
Specimen S4a E12.5 injected: embryonic day 15.5 (more )
Note: Double labeled: red - Ebf1; green - BrdU injected at E12.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted S4a E12.5 injected Medial boxed area , S4a E12.5 injected , S4a E12.5 injected Lateral boxed area Expression is in striatonigral neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory