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Gene Expression Data
Assay Details
Assay
Reference: J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8270625
Gene symbol: Foxp1
Gene name: forkhead box P1
Antibody: anti-Foxp1 (ab16645)
Detection system: Secondary antibody coupled to Alexa Fluor
Assay notes: Nolz1-/- mutant embryos, in which the coding region of Nolz1 has been replaced by beta-Galactosidase (also referred to as Nolz1<bgal/bgal>). Zfp503<tm1.1Bpb> (neo cassette removed) has been used in the annotations, but it could be Zfp503<tm1Bpb> (neo cassette still present).
Results
Specimen 2k: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: corpus striatum striatum neuron Present Regionally restricted 2k Expression is detected in striatal projection neurons.
Specimen 2l: embryonic day 18.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Structure Level Pattern Image Note
TS26: corpus striatum Weak 2l Expression is downregulated in Nolz1-/- striatum.
Specimen 4f WT E10.5 injected: embryonic day 15.5 (more )
Note: Double labeled: red - Foxp1; green - BrdU injected at E10.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 4f WT E10.5 injected , 4f WT E10.5 injected high mag Expression is detected in striatal projection neurons.
Specimen 4f Nolz1-/- E10.5 injected: embryonic day 15.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: red - Foxp1; green - BrdU injected at E10.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 4f Nolz1-/- E10.5 injected high mag , 4f Nolz1-/- E10.5 injected Expression is detected in striatal projection neurons.
Specimen 4f WT E11.5 injected: embryonic day 15.5 (more )
Note: Double labeled: red - Foxp1; green - BrdU injected at E11.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 4f WT E11.5 injected , 4f WT E11.5 injected high mag Expression is detected in striatal projection neurons. The majority of the neurons labelled by BrdU resulting from injections at E11.5 and E12.5 expresses FOXP1.
Specimen 4f Nolz1-/- E11.5 injected: embryonic day 15.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: red - Foxp1; green - BrdU injected at E11.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 4f Nolz1-/- E11.5 injected high mag , 4f Nolz1-/- E11.5 injected Expression is detected in striatal projection neurons.
Specimen 4f WT E12.5 injected: embryonic day 15.5 (more )
Note: Double labeled: red - Foxp1; green - BrdU injected at E12.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 4f WT E12.5 injected high mag Lateral , 4f WT E12.5 injected , 4f WT E12.5 injected high mag Medial Expression is detected in striatal projection neurons. The majority of the neurons labelled by BrdU resulting from injections at E11.5 and E12.5 expresses FOXP1.
Specimen 4f Nolz1-/- E12.5 injected: embryonic day 15.5; Zfp503tm1.1Bpb/Zfp503tm1.1Bpb (more )
Note: Double labeled: red - Foxp1; green - BrdU injected at E12.5.
Structure Cell Type Level Pattern Image Note
TS23: corpus striatum striatum neuron Present Regionally restricted 4f Nolz1-/- E12.5 injected Medial , 4f Nolz1-/- E12.5 injected , 4f Nolz1-/- E12.5 injected Lateral Expression is detected in striatal projection neurons.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory