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Gene Expression Data
Assay Details
Assay
Reference: J:366215 Rudat C, et al., PPARG contributes to urothelial integrity in the murine ureter by activating the expression of Shh and superficial cell-specific genes. Development. 2025 Apr 15;152(8)
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8268818
Gene symbol: Acta2
Gene name: actin alpha 2, smooth muscle, aorta
Antibody: Anti-smooth muscle alpha-Actin (clone 1A4)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2D ACTA2 control: postnatal day 40; Ppargtm2Rev/? (more )
Structure Cell Type Level Pattern Image Note
TS28: ureter ureter smooth muscle cell Present 2D ACTA2 control
Specimen 2D ACTA2 cKO: postnatal day 40; Ppargtm2Rev/Ppargtm2Rev, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: ureter Weak Regionally restricted 2D ACTA2 cKO Expression irregular, slightly reduced compared to control.
Specimen 3C ACTA2 E14.5 control: embryonic day 14.5; Ppargtm2Rev/? (more )
Structure Level Pattern Image Note
TS22: ureter Absent 3C ACTA2 E14.5 control
Specimen 3C ACTA2 E14.5 cKO: embryonic day 14.5; Ppargtm2Rev/Ppargtm2Rev, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: ureter Absent 3C ACTA2 E14.5 cKO
Specimen 3C ACTA2 E16.5 control: embryonic day 16.5; Ppargtm2Rev/? (more )
Structure Cell Type Level Pattern Image Note
TS24: ureter ureter smooth muscle cell Present 3C ACTA2 E16.5 control Expression in smooth muscle cells starting at E16.5.
Specimen 3C ACTA2 E16.5 cKO: embryonic day 16.5; Ppargtm2Rev/Ppargtm2Rev, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS24: ureter ureter smooth muscle cell Present 3C ACTA2 E16.5 cKO Expression indistinguishable from control.
Specimen 3C ACTA2 E18.5 control: embryonic day 18.5; Ppargtm2Rev/? (more )
Structure Level Pattern Image Note
TS26: ureteral mesenchyme Present 3C ACTA2 E18.5 control Expression continued in mesenchymal wall of ureter.
Specimen 3C ACTA2 E18.5 cKO: embryonic day 18.5; Ppargtm2Rev/Ppargtm2Rev, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: ureteral mesenchyme Present 3C ACTA2 E18.5 cKO Expression indistinguishable from control.
Specimen 3C ACTA2 P7 control: postnatal day 7; Ppargtm2Rev/? (more )
Structure Level Pattern Image Note
TS28: ureter Present Regionally restricted 3C ACTA2 P7 control Expression continued in mesenchymal wall of ureter.
Specimen 3C ACTA2 P7 cKO: postnatal day 7; Ppargtm2Rev/Ppargtm2Rev, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: ureter Present Regionally restricted 3C ACTA2 P7 cKO Expression indistinguishable from control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/06/2026
MGI 6.29 		The Jackson Laboratory