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Gene Expression Data
Assay Details
Assay
Reference: J:373931 Welton JM, et al., Loss of CMTR1 leads to gastrulation failure and early embryonic lethality. Dev Biol. 2025 Dec;528:1-12
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8262938
Gene symbol: Trp53
Gene name: transformation related protein 53
Antibody: anti-phospho-p53 (#9284)
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 3D Control: embryonic day 6.5 (more )
Note: Littermate control; Multi-labeled: green - Trp53; magenta - Cdx2 (assay MGI:8262937); white - Pou5f1 (assay MGI:8262936); blue - DAPI.
Structure Level Pattern Image Note
TS9: embryo Present Single cells 3D Control Merge , 3D Control P53 , 3D Control inset Expression is seen in apoptotic cells.
TS9: extraembryonic ectoderm Present Single cells 3D Control Merge , 3D Control P53 Expression is seen in apoptotic cells.
Specimen 3D KO: embryonic day 6.5; Cmtr1em1(IMPC)J/Cmtr1em1(IMPC)J (more )
Note: Multi-labeled: green - Trp53; magenta - Cdx2 (assay MGI:8262937); white - Pou5f1 (assay MGI:8262936); blue - DAPI.
Structure Level Pattern Image Note
TS9: embryo Present Single cells 3D KO P53 , 3D KO Merge , 3D KO inset Expression is seen in apoptotic cells. Their number is significantly increased in mutant embryos.
TS9: extraembryonic ectoderm Present Single cells 3D KO P53 , 3D KO Merge Expression is seen in apoptotic cells. The number seen in mutants is the same as in wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory