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Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: RT-PCR
MGI Accession ID: MGI:8187774
Gene symbol: Hnf1b
Gene name: HNF1 homeobox B
Probe: Hnf1b-pF, Hnf1b-pR
Assay notes: Quantitative RT-PCR. Relative expression was normalized to Ppia.
Results
Image: 1A ©

 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified Amount Genetic BackgroundMutant Allele(s)Sex
E14.5 WT E14.5 TS22: metanephros Present Not Specified Not Specified Not Specified
E14.5 Sp2/+ E14.5 TS22: metanephros Weak (a) Not Specified involves: 129 Hnf1btm2.1Sce/Hnf1b+Not Specified
E15.5 WT E15.5 TS23: metanephros Present Not Specified Not Specified Not Specified
E15.5 Sp2/+ E15.5 TS23: metanephros Weak (b) Not Specified involves: 129X1/SvJ Hnf1atm1.1Ylee/Hnf1atm1.1YleeNot Specified
E16.5 WT E16.5 TS24: metanephros Present Not Specified Not Specified Not Specified
E16.5 Sp2/+ E16.5 TS24: metanephros Weak (b) Not Specified involves: 129 Hnf1btm2.1Sce/Hnf1b+Not Specified
E17.5 WT E17.5 TS25: metanephros Present Not Specified Not Specified Not Specified
E17.5 Sp2/+ E17.5 TS25: metanephros Weak (c) Not Specified involves: 129 Hnf1btm2.1Sce/Hnf1b+Not Specified
P0 WT P0 TS27: metanephros Present Not Specified Not Specified Not Specified
P0 Sp2/+ P0 TS27: metanephros Weak (d) Not Specified involves: 129 Hnf1btm2.1Sce/Hnf1b+Not Specified
Adult WT P m 3 TS28: metanephros Present Not Specified Not Specified Not Specified
Adult Sp2/+ P m 3 TS28: metanephros Present (e) Not Specified involves: 129 Hnf1btm2.1Sce/Hnf1b+Not Specified
Adult WT P m 5 TS28: metanephros Present Not Specified Not Specified Not Specified
Adult Sp2/+ P m 5 TS28: metanephros Present (e) Not Specified involves: 129 Hnf1btm2.1Sce/Hnf1b+Not Specified
Notes:
(a) Expression significantly decreased (58.5%) compared to wild type.
(b) Expression significantly decreased (57%) compared to wild type.
(c) Expression significantly decreased (50%) compared to wild type.
(d) Expression significantly decreased (64%) compared to wild type.
(e) Reduction in transcript levels was highly variable and modest, not reaching significance.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory