About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8187735
Gene symbol: Lrp2
Gene name: low density lipoprotein receptor-related protein 2
Antibody: anti-LRP2
Assay notes: Embryos and postnatal kidneys up to 2 months of age were fixed with 60% ethanol/11% formaldehyde and 10% acetic acid.
Results
Specimen 7D: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: metanephros Present 7D
Specimen 7D': embryonic day 17.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS25: metanephros Weak 7D' Expression moderately reduced compared to wild type.
Specimen S8 Megalin WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_Megalin WT
Specimen S8 Megalin Sp2/+: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Trace S8_Megalin Sp2/+ Expression strongly dowregulated compared to wild type.
Specimen S8 Megalin Hnf1a-/-: embryonic day 16.5; Hnf1atm1.1Ylee/Hnf1atm1.1Ylee (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_Megalin Hnf1a-/- Expression not dowregulated compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory