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Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8187733
Gene symbol: Cubn
Gene name: cubilin
Antibody: anti-CUBN
Assay notes: Embryos and postnatal kidneys up to 2 months of age were fixed with 60% ethanol/11% formaldehyde and 10% acetic acid.
Results
Specimen 7B: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: metanephros Present 7B
Specimen 7B': embryonic day 17.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS25: metanephros Trace 7B' Expression strongly reduced compared to wild type.
Specimen S8 Cubilin WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_Cubulin WT
Specimen S8 Cubilin Sp2/+: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Weak Regionally restricted S8_Cubulin Sp2/+ Expression strongly downregulated compared to wild type.
Specimen S8 Cubilin Hnf1a-/-: embryonic day 16.5; Hnf1atm1.1Ylee/Hnf1atm1.1Ylee (more )
Structure Level Pattern Image Note
TS24: cortical early proximal tubule Present S8_Cubulin Hnf1a-/- Expression not downregulated compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory