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Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8187724
Gene symbol: Wt1
Gene name: WT1 transcription factor
Antibody: anti-WT1 (C-19; sc-192)
Assay notes: Embryos and postnatal kidneys up to 2 months of age were fixed with 60% ethanol/11% formaldehyde and 10% acetic acid.
Results
Specimen 3D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present 3D Expression in developing glomeruli.
TS24: cap mesenchyme Present 3D Expression in condensed mesenchyme.
Specimen 3D': embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Weak 3D' inset , 3D'
Specimen 4C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted 4C Expression in glomerular cyst.
Specimen 4F: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted 4F Expression in podocyte layer of non-cystic glomeruli and disorganized podocyte layer of glomerular cysts.
Specimen 4I: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted 4I Expression in podocyte layer of non-cystic glomeruli and disorganized podocyte layer of glomerular cysts.
Specimen S3C WT1 WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: maturing glomerular tuft Present S3C WT1 WT
Specimen S3C WT1 Sp2/+: embryonic day 14.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS22: maturing glomerular tuft Present S3C WT1 Sp2/+ higher mag , S3C WT1 Sp2/+
Specimen S11: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS23: maturing glomerular tuft Present S11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory