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Gene Expression Data
Assay Details
Assay
Reference: J:306107 Niborski LL, et al., Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8187722
Gene symbol: Pax2
Gene name: paired box 2
Antibody: anti-Pax2 (#901001, #PRB-276P)
Assay notes: Embryos and postnatal kidneys up to 2 months of age were fixed with 60% ethanol/11% formaldehyde and 10% acetic acid.
Results
Specimen 3A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: metanephros Present 3A
Specimen 3A': embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS23: metanephros Present 3A' Expression not affecred compared to wild type.
Specimen 5G: embryonic day 15.5 (more )
Note: Double labeled: green - Pax2; red - acetylated tubulin.
Structure Level Pattern Image Note
TS23: metanephros Present 5G
Specimen 5H: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Note: Double labeled: green - Pax2; red - acetylated tubulin.
Structure Level Pattern Image Note
TS23: metanephros Present 5H
Specimen 5I: embryonic day 15.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Note: Double labeled: green - Pax2; red - acetylated tubulin.
Structure Level Pattern Image Note
TS23: metanephros Present 5I
Specimen S3B Pax2 WT: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: metanephros Present Regionally restricted S3B Pax2 WT inset , S3B Pax2 WT Expression in induced metanephric mesenchyme, ureteric bud branches, nascent nephrons, renal vesicles and s-shaped bodies.
Specimen S3B Pax2 Sp2/+: embryonic day 14.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS22: metanephros Present S3B Pax2 Sp2/+ upper left , S3B Pax2 Sp2/+ , S3B Pax2 Sp2/+ lower right Expression not affecred compared to wild type.
Specimen S3C Pax2 E16.5 WT: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: metanephros Present S3C Pax2 E16.5 WT
Specimen S3C Pax2 E16.5 Sp2/+: embryonic day 16.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS24: metanephros Present S3C Pax2 E16.5 Sp2/+ Expression pattern similar to wild type.
Specimen S3C Pax2 E18.5 WT: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: metanephros Present S3C Pax2 E18.5 WT
Specimen S3C Pax2 E18.5 Sp2/+: embryonic day 18.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Structure Level Pattern Image Note
TS26: metanephros Present S3C Pax2 E18.5 Sp2/+ Expression pattern similar to wild type.
Specimen S6A WT: embryonic day 14.5 (more )
Note: Double labeled: green - Pax2; red - phosphohistone H3.
Structure Level Pattern Image Note
TS22: metanephros Present S6A WT
Specimen S6A Sp2/+: embryonic day 14.5; Hnf1btm2.1Sce/Hnf1b+ (more )
Note: Double labeled: green - Pax2; red - phosphohistone H3.
Structure Level Pattern Image Note
TS22: metanephros Present S6A Sp2/+
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory