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Gene Expression Data
Assay Details
Assay
Reference: J:245758 Carreno G, et al., Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8175745
Gene symbol: Pomc
Gene name: pro-opiomelanocortin-alpha
Results
Specimen S7A: embryonic day 12.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shh+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hypothalamus Present Regionally restricted S7A Expression was detected in the anterior hypothalamus of control embryos.
Specimen S7B: embryonic day 12.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shhtm2.1Amc (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: hypothalamus Absent S7B
Specimen S13E: embryonic day 14.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pituitary gland Present S13E
Specimen S13F: embryonic day 14.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1tm1Hahn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pituitary gland Present S13F The expression domain is enlarged in the mutant compared with control embryos.
Specimen S14E: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: pituitary gland corticotroph Present S14E
TS26: pituitary gland melanocyte stimulating hormone secreting cell Present S14E
Specimen S14F: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1tm1Hahn (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: pituitary gland corticotroph Present S14F Cell commitment and differentiation of hormone-producing cells was not prevented in the Hesx1<Cre/+>;Ptch1<fl/fl> mutants.
TS26: pituitary gland melanocyte stimulating hormone secreting cell Present S14F Cell commitment and differentiation of hormone-producing cells was not prevented in the Hesx1<Cre/+>;Ptch1<fl/fl> mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory