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Gene Expression Data
Assay Details
Assay
Reference: J:245758 Carreno G, et al., Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8175729
Gene symbol: Pou1f1
Gene name: POU domain, class 1, transcription factor 1
Antibody: Anti-PIT1
Results
Specimen S6C: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shh+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: pituitary gland Present S6C Immunostaining labels most of the pituitary cells in the control at E18.5.
Specimen S6D: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shhtm2.1Amc (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: pituitary gland Absent S6D
Specimen S13C: embryonic day 14.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pituitary gland Present S13C
Specimen S13D: embryonic day 14.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1tm1Hahn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pituitary gland Present S13D The expression domain is enlarged in the mutant compared with control embryos.
Specimen S14A: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1+ (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: pituitary gland mammotroph Present S14A
TS26: pituitary gland somatotroph Present S14A
TS26: pituitary gland thyrotroph Present S14A
Specimen S14B: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1tm1Hahn (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS26: pituitary gland mammotroph Present S14B Cell commitment and differentiation of hormone-producing cells was not prevented in the Hesx1<Cre/+>;Ptch1<fl/fl> mutants.
TS26: pituitary gland somatotroph Present S14B Cell commitment and differentiation of hormone-producing cells was not prevented in the Hesx1<Cre/+>;Ptch1<fl/fl> mutants.
TS26: pituitary gland thyrotroph Present S14B Cell commitment and differentiation of hormone-producing cells was not prevented in the Hesx1<Cre/+>;Ptch1<fl/fl> mutants.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory