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Gene Expression Data
Assay Details
Assay
Reference: J:245758 Carreno G, et al., Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8174599
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Results
Specimen 5W: embryonic day 10.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shh+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted 5W Expression is detected in the hypothalamus of control embryos.
TS17: Rathke's pouch Present Regionally restricted 5W Expression is detected in the Rathke's pouch epithelium.
Specimen 5X: embryonic day 10.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shhtm2.1Amc (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted 5X Expression in the hypothalamus is comparable between the control and mutant embryo.
TS17: Rathke's pouch Present Regionally restricted 5X Expression in the Rathke's pouch epithelium is comparable between the control and mutant embryo.
Specimen 9A: embryonic day 14.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pituitary gland Present 9A
Specimen 9B: embryonic day 14.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1tm1Hahn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: pituitary gland Present 9B Expression in the mutant is comparable to control at E14.5.
Specimen 9C: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: pituitary gland Present 9C , 9C'
Specimen 9D: embryonic day 18.5; Hesx1tm1(cre)Jpmb/Hesx1+, Ptch1tm1Hahn/Ptch1tm1Hahn (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: pituitary gland Present 9D , 9D' Expression is expanded in the mutant pituitary relative to the control at E18.5.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory