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Gene Expression Data
Assay Details
Assay
Reference: J:245758 Carreno G, et al., Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8174544
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Results
Specimen 5Q: embryonic day 10.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shh+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted 5Q Expression is detected in the posterior hypothalamus, with a sharp boundary at the level where the infundibulum will develop. A negative region encompasses the anterior hypothalamus.
TS17: telencephalon Present Regionally restricted 5Q Expression is detected in the ventral telencephalon.
Specimen 5R: embryonic day 10.5; Hesx1tm1(cre)Jpmb/Hesx1+, Shhtm2Amc/Shhtm2.1Amc (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted 5R In the Hesx1<Cre/+>;Shh<fl/-> mutants, the expression domain was broadly observed throughout the hypothalamus with no detectable negative area in the neuroepithelium, suggesting that the anterior hypothalamus was missing.
TS17: telencephalon Present Regionally restricted 5R Expression is detected in the ventral telencephalon.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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