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Gene Expression Data
Assay Details
Assay
Reference: J:175361 Nakano I, et al., Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 Aug 1;170(3):413-27
Assay type: RNA in situ
MGI Accession ID: MGI:7865053
Gene symbol: Melk
Gene name: maternal embryonic leucine zipper kinase
Probe: MELK probe
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 2Ba: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: future brain Present Regionally restricted 2Ba Expressed within the periventricular developing germinal zones.
Specimen 2Bb: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: brain Present Regionally restricted 2Bb Expressed within the periventricular developing germinal zones.
Specimen 2Bc: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: brain Present Regionally restricted 2Bc Expressed within the periventricular developing germinal zones.
TS21: brain subventricular zone Present 2Bc
Specimen 2Bd: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: brain Present Regionally restricted 2Bd Expressed within the periventricular developing germinal zones.
TS23: brain subventricular zone Present 2Bd
Specimen 2Bh: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present Regionally restricted 2Bh Expressed in the anterior subventricular zone.
TS28: rostral migratory stream Present 2Bh
Specimen 2Bi: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present Regionally restricted 2Bi Expressed in the subventricular zone lining the lateral ventricle along its entire rostrocaudal extent, but within only a minority of cells along the lateral side.
Specimen 2Da: postnatal adult (more )
Note: Double labeled: black - Melk; brown - Gfap (assay MGI:7865055).
Structure Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present 2Da right , 2Da left
Specimen 2Db: postnatal adult (more )
Note: Double labeled: black - Melk; brown - Gfap (assay MGI:7865055).
Structure Level Pattern Image Note
TS28: hippocampus Absent 2Db left , 2Db right
Specimen 3Aa/b: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Pcna (assay MGI:7865089).
Structure Level Pattern Image Note
TS28: brain subventricular zone Present Regionally restricted 3Ab , 3Aa Expressed by Pcna+ cells.
Specimen 3Ac/d: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Pcna (assay MGI:7865089).
Structure Level Pattern Image Note
TS28: brain subventricular zone Present Regionally restricted 3Ad , 3Ac Expressed by Pcna+ cells.
Specimen 3Ae: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Pcna (assay MGI:7865089).
Structure Level Pattern Image Note
TS28: rostral migratory stream Present 3Ae Coexpressed with Pcna.
Specimen 3Af: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Pcna (assay MGI:7865089).
Structure Level Pattern Image Note
TS28: nose Absent 3Af
Specimen 3Ba: postnatal day 1 (more )
Note: Double labeled: black - Melk; brown - Gfap (assay MGI:7865055).
Structure Level Pattern Image Note
TS27: cerebral cortex subventricular zone Weak 3Ba Most MELK-expressing cells were GFAP-negative.
Specimen 3Bb: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Gfap (assay MGI:7865055).
Structure Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present 3Bb MELK mRNA was detected in some GFAP-expressing cells.
Specimen 3Bc: postnatal adult (more )
Note: Double labeled: black - Melk; brown - Gfap (assay MGI:7865055).
Structure Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present 3Bc MELK expression was also detectable in GFAP-positive cells.
Specimen 3Ca: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Gfap (assay MGI:7865055).
Structure Level Pattern Image Note
TS28: dentate gyrus hilus Present 3Ca Expressed within GFAP-positive cells at the hilar border.
Specimen 3Cb: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Tubb3 (assay MGI:7865141).
Structure Level Pattern Image Note
TS28: dentate gyrus hilus Present 3Cb Expressed within GFAP-positive cells at the hilar border. No expression in Tuj1/Tubb3-positive neurons.
Specimen 3Da/b: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Tubb3 (assay MGI:7865141).
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 3Db , 3Da
Specimen 3Dc: postnatal day 7 (more )
Note: Double labeled: black - Melk; brown - Tubb3 (assay MGI:7865141).
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 3Dc
TS28: cerebellum internal granule cell layer Absent 3Dc
Specimen 9Bb E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: brain subventricular zone Present 9Bb MELK E13
Specimen 9Bb E15: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: brain subventricular zone Present 9Bb MELK E15
Specimen 9Bb P7 upper: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebral cortex subventricular zone Present 9Bb MELK P7 upper
Specimen 9Bb P7 lower: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: cerebellum Present 9Bb MELK P7 lower
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/08/2026
MGI 6.24 		The Jackson Laboratory