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Gene Expression Data
Assay Details
Assay
Reference: J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7857189
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: Anti-Sox2 (Clone 245610; MAB2018)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen S4A: embryonic day 18.5 (more )
Note: Apex of cochlea. Double labeled: green - Sox2; red - Myo7a (assay MGI:7857188).
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted S4A Expression in sensory progenitors.
Specimen S4B: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Apex of cochlea. Double labeled: green - Sox2; red - Myo7a (assay MGI:7857188).
Structure Level Pattern Image Note
TS26: cochlear duct Present S4B Sensory progenitors present in requisite number at apex of cochlear duct.
Specimen S4D: embryonic day 18.5 (more )
Note: Base of cochlea. Double labeled: green - Sox2; red - Myo7a (assay MGI:7857188).
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct supporting cell of cochlea Present S4D
Specimen S4E: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Base of cochlea. Double labeled: green - Sox2; red - Myo7a (assay MGI:7857188).
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct supporting cell of cochlea Present S4E Similar number and organization of support cells (pillar and Deiter cells) at basal turn compared to control.
Specimen S4L: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cochlear duct Present Regionally restricted S4L Expression in sensory progenitors.
Specimen S4M: embryonic day 14.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS22: cochlear duct Present S4M No difference in expression in sensory progenitors compared to control.
Specimen 4T/U: postnatal day 0 (more )
Note: Double labeled: green - Sox2; red - Myo7a (assay MGI:7857188).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlea auditory hair cell Weak 4U , 4T
Specimen 4W/X: postnatal day 0; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Double labeled: green - Sox2; red - Myo7a (assay MGI:7857188).
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 4X , 4W Authors report failure to downregulated expression in hair cell nuclei.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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